Gd_(2)O_(3)@SiO_(2) nanoparticles with a core-shell structure are synthesized by pulsed laser ablation in liquid(PLAL)in single steps.A Gd_(2)O_(3) target immersed in tetraethyl orthosilicate(TEOS)is ablated by a microsecond Nd:YAG laser,which induces the generation of a Gd_(2)O_(3) plasma plume and pyrolysis of the TEOS.We propose that the moment Gd_(2)O_(3) nanoparticles are formed they will be coated immediately by SiO_(2) and directly synthesized Gd_(2)O_(3)@SiO_(2) core-shell nanoparticles.These particles obtain high r1 relaxivity of 5.26 s^(-1)mM^(-1) and are used as T_(1)-weighted magnetic resonance imaging contrast agents.It is shown that the PLAL technique is promising for fabricating core-shell structure nanomaterial with potential medical applications.
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