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《中国科学通报：英文版》
>Expression of neurotrophin-3 mRNA induced by limbic seizuresin adult rat hippocampus
Expression of neurotrophin-3 mRNA induced by limbic seizuresin adult rat hippocampus
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摘要
Kainic acid(KA),a prospective neuroexcitable and neurotoxic analog of glumate,inducespersistent seizure activity in limbic structures which results in behavioral symptoms,electrographic and neuropathologic alternations closely resembling human temporal lobe epi-lepsy.The hippocampal pyramidal cells possess abundant KA high affinity binding sites intheir membranes and are extremely vulnerable to KA neurotoxicity.NT-3 is a memberof the neurotrophic family(NTF)including nerve growth factor(NGF),brain derivedneurotrophic factor(BDNF),neurotrophin-4/5(NF-4/5).NT-3 mRNA was expressed
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