BECAUSE of lacking fibrin selectivity two chain urokinase-type plasminogen activator(tcu-PA),which has been used as the clinical thrombolytic agent,may lead to bleeding by a remarkabledepletion of fibrinogen in plasma when injected in large doses,thus its clinical application islimited.Single chain urokinase-type plasminogen activator(scu-PA)is the precursor of tcu-
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