Polymeric adsorbents with peptide pendants as artificial receptors for β-Mactam antibiotics by mimicking the binding sites of β-lactamases

马建标; 谢志东; 王永健; 王亦农; 范云鸽; 何炳林

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Polymeric adsorbents with peptide pendants as artificial receptors for β-Mactam antibiotics by mimicking the binding sites of β-lactamases

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A scries of polymeric adsorbents with peptide pendants were designed as the artificial receptors of β-laetarn antibiotics by mimicking the structures of binding site in β-lactamases.Crosslinked poly(N,N-dimethyl acry-lamide) gel as a carrier was prepared by suspension copolyrnerization of N,N-dimethyl acrylamide and N,N-bisacryl-diaminoethane and then functionalized with ethylenediamine after partial hydrolysis.Using solid-phase peptide synthesis with symmetrical anhydride of protected amino acid step by step,various peptide pendants were respectively anchored onto the functionalized carrier.The adsorption properties of these peptide-containing adsorbents for β-lactam antibiotics such as ampicillin and cefotaxime were then studied.The results showed that only those adsorbents in which peptide chains contained more than one lysine residues could obviously adsorb both β-lactams and that static interaction as well as hydrogen bond played an important role during the adsorption

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《中国科学》 |1997年第4期|P.405-411|共7页
作者
马建标; 谢志东; 王永健; 王亦农; 范云鸽; 何炳林;
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作者单位

[1]State Key Laboratory of Functional Polymer Materials for Adsorption and Separation;

[2]Institute of Polymer Chemistry;

[3]Nankai University;

[4]Tianjin 300071;

[5]China;

[6]China;

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原文格式 PDF
正文语种 CHI
中图分类吸附;
关键词
biomimetic polymer polymeric adsorbent p-lactamase p-lactam antibiotics;

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Polymeric adsorbents with peptide pendants as artificial receptors for β-Mactam antibiotics by mimicking the binding sites of β-lactamases

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