CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells

Dai Xiaoyan; Xin Yanli; Xu Weizhi; Tian Xinria; Wei Xiaofan; Zhang Hongquan

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CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells

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Slug,a member of the Snail family of transcriptional repressors,plays a key role in cancer progression,cellular plasticity,and epithelial to mesenchymal transition(EMT).Slug is a fast turnover protein and its stabilty is controlled by post-translational modifications.Here,we identified that Slug is acetylated by acetyltransferase CREB-binding protein(CBP)in breast cancer cells.CBP directly interacts with the C-terminal domain of Slug through its catalytic histone acetyltransferase(HAT)domain,leading to acetylation of Slug at lysines 166 and 211.

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《解剖学杂志》 |2021年第s01期|197-197|共1页
作者
Dai Xiaoyan; Xin Yanli; Xu Weizhi; Tian Xinria; Wei Xiaofan; Zhang Hongquan;
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作者单位

Department of Human Anatomy;

Histology;

and Embryology;

Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)and State Key Laboratory of Natural and Biomimetic Drugs;

School of Basic Medical Sciences;

Peking University Health Science Center;

Beijing 100191;

Department of Pathology;

School of Basic Medical Sciences;

Peking University Health Science Center;

Beijing 100191;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Slug; breast; cancer;

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CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells

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