Cryo-EM structure determination captures new chemical modification of protein

Hualiang Jiang

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Cryo-EM structure determination captures new chemical modification of protein

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With the discovery of the“central dogma”of life science,the molecular mechanism of genetics and evolution of biological species has basically been established.However,the completion of the Human Genome Project at the turn of the 21st century has begun to uncover the complexity of individual lives.Although the evolution of living individuals depends mainly on the sequence of genes,its complexity and diversity cannot be explained by the“central dogma”alone.Biomolecules,including proteins,nucleic acids and polysaccharides,are the basic“building blocks”of life,providing the material basis for living processes,and are subject to dynamic chemical modifications and regulation.The dynamic chemical modifications of these biomolecules play a key role in the development of individual organisms and in the regulation of cell fate,and also play a decisive role in the onset and development of diseases.

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《中国科学》 |2021年第10期|P.1781-1783|共3页
作者
Hualiang Jiang;
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作者单位

State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 ChinaShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech University Shanghai 201210 China;

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原文格式 PDF
正文语种 chi
中图分类中国工业经济;
关键词
chemical; alone; modification;

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Cryo-EM structure determination captures new chemical modification of protein

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