目的：探讨非妊娠性绒毛膜癌的临床表现、病理特征、治疗和预后情况。方法回顾性分析该院4例非妊娠性绒毛膜癌患者的临床及病理资料，并复习相关文献。结果4例患者初诊均未得到明确诊断，所有患者均接受手术治疗及术后行 BEP方案化疗；随访3～32个月。1例术后26个月时因肺转移死亡；1例失访；2例一般情况可。结论非妊娠性绒毛膜癌是罕见的高度侵袭性的滋养叶细胞肿瘤，易早期发生血行转移，治疗推荐采用手术及术后结合多药联合化疗。%Objective To investigate the clinical manifestations,pathological features,treatment and prognosis of nongesta-tional choriocarcinomas.Methods The clinicopathological data in 4 cases of nongestational choriocarcinoma were retrospectively analyzed and the relevant literatures were reviewed.Results All 4 patients had no confirmed diagnosis at first visit to hospital.All patients received the operative therapy and postoperative bleomycin,etoposide and cis-platinum (BEP)regimen chemotherapy.The followed up lasted for 3-32 months.One case died at postoperative 26 months due to pulmonary metastasis;one case was loss of follow up;two cases had relatively favorable condition.Conclusion Nongestational choriocarcinoma is a rare and highly invasive trophoblastic neoplasm,and is prone for early distant metastasis.The treatment is recommended to adopt operation combined with postoperative combined chemotherapy of multiple drugs.
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