Objective To study the correlation between thyroid autoantibodies anti‐thyroid peroxidase antibody (TPOAb) with recurrent miscarriage to seek the objective data indicator for clinical diagnosis of recurrent miscarriage .Methods A total of 1 016 pregnant women of physical examination and normal thyroid function in the obstetric and gynecologic clinic of our hospital from March 2012 to May 2014 were selected as the research subjects .Among them ,90 cases of abortion were screened out and di‐vided into the primary abortion group(60 cases) and the recurrent abortion group(30 cases) .90 healthy childbearing age women of physical examination were selected as the control group .The positive TPOAb cases were performed statistics and compared among various groups ,the ratio was calculated;the TPOAb level was recorded in each group .At the same time the correlation between TPOAb with recurrent abortion was analyzed .Results The TPOAb positive rate in the recurrent abortion group was 46 .67% , which was significantly higher than 25 .00% in the primary abortion group and 4 .44% in the control group;at the same time the TPOAb positive rate of primary abortion group was also significantly higher than that of the control group ,the difference had sta‐tistical significance (P<0 .05) .The TPOAb concentration level in the recurrent abortion group was significantly higher than that in the primary abortion group and the control group;the TPOAb concentration level in the primary abortion group was also signifi‐cantly higher than that in the control group ,the differences were statistically significant (P< 0 .05) .In the follow‐up of adverse pregnancy occurrence with recurrent abortion as the adverse pregnancy event ,and according to the method of Spearman correlation analysis ,with the increase of TPOAb level ,the occurrence rate of recurrent miscarriage was higher ,which showed the positive cor‐relation(r=0 .764 ,P=0 .000) .Conclusion Monitoring the patient′s TPOAb level can better show the symptoms of recurrent abor‐tion .%目的：研究分析甲状腺自身抗体抗甲状腺过氧化物酶抗体（TPOAb）与复发性流产的相关性，为临床诊断复发性流产寻找客观的数据指标。方法选择2012年3月至2014年5月在该院进行体检的妇产科门诊甲状腺功能正常的孕早期妇女1016例作为研究对象，筛选出其中的90例流产患者分成两组，原发性流产组60例，复发性流产组30例，另选90例体检健康的育龄女性作为对照组，统计并对比各组的TPOAb阳性例数，计算比率；记录各组 TPOAb水平，同时分析 TPOAb与复发性流产的相关性。结果复发性流产组的T PO A b阳性率为46．67％，显著高于原发性流产组的25．00％，以及对照组的4．44％；同时原发性流产组的TPOAb阳性率亦显著高于对照组，差异均有统计学意义（均 P＜0．05）。复发性流产组的TPOAb水平显著高于原发性流产组和对照组的水平；同时原发性流产组的 TPOAb浓度水平亦显著高于对照组的水平，差异均有统计学意义（均 P＜0．05）。随访不良妊娠发生情况，以复发性流产为不良妊娠事件，并根据Spearman法分析相关性可知，随着 TPOAb水平的增加，复发性流产的发生率增高，二者之间呈正相关（ r＝0．764，P＝0．000）。结论监测患者 T PO A b水平，可较好地呈现复发性流产的症状情况。
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