Quantitative image analysis for evaluation of tumor response in clinical oncology

Wen-Li Cai; Guo-Bin Hong

摘要

The objective, accurate, and standardized evaluation of tumor response to treatment is an indispensable procedure in clinical oncology. Compared to manual measurement, computer-assisted linear measurement can significantly improve the accuracy and reproducibility of tumor burden quantification. For irregular-shaped and infiltrating or diffuse tumors, which are difficult to quantify by linear measurement, computer-assisted volumetric measurement may provide a more objective and sensitive quantification to evaluate tumor response to treatment than linear measurement does. In the evaluation of tumor response to novel oncologic treatments such as targeted therapy, changes in overall tumor size do not necessarily reflect tumor response to therapy due to the presence of internal necrosis or hemorrhages. This leads to a new generation of imaging biomarkers to evaluate tumor response by using texture analysis methods, also called radiomics. Computer-assisted texture analysis technology offers a more comprehensive and in-depth imaging biomarker to evaluate tumor response. The application of computer-assisted quantitative imaging analysis techniques not only reduces the inaccuracy and improves the reliability in tumor burden quantification, but facilitates the devel-opment of more comprehensive and intelligent approaches to evaluate treatment response, and hence promotes precision imaging in the evaluation of tumor response in clinical oncology. This article summarizes the state-of-the-art technical developments and clinical applications of quantitative imaging analysis in evaluation of tumor response in clinical oncology.

机译：客观，准确和标准化的肿瘤对治疗反应的评估是临床肿瘤学中必不可少的步骤。与手动测量相比，计算机辅助线性测量可以显着提高肿瘤负荷定量的准确性和可重复性。对于难以通过线性测量量化的不规则形状和浸润性或弥漫性肿瘤，计算机辅助体积测量可能比线性测量提供更客观和敏感的量化来评估肿瘤对治疗的反应。在评估针对新型肿瘤治疗方法（例如靶向治疗）的肿瘤反应时，由于存在内部坏死或出血，总体肿瘤大小的变化不一定反映肿瘤对治疗的反应。这导致新一代的成像生物标记物通过使用质地分析方法（也称为放射线学）来评估肿瘤反应。计算机辅助纹理分析技术可提供更全面，更深入的成像生物标记物，以评估肿瘤反应。计算机辅助定量成像分析技术的应用不仅减少了不准确度，提高了肿瘤负荷定量的可靠性，而且促进了开发更全面，更智能的方法来评估治疗反应，从而促进了精确成像的评估。临床肿瘤学中的肿瘤反应。本文总结了定量成像分析在评估临床肿瘤学中肿瘤反应方面的最新技术发展和临床应用。

Quantitative image analysis for evaluation of tumor response in clinical oncology

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