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《海岸生命医学杂志(英文版)》
>Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Cassia alata for skin diseases
Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Cassia alata for skin diseases
Objective: To explore the antifungal and antibacterial activity of methanolic extract of Cassiaalata(C. alata) and its formulations for skin diseases. Methods: Sundried leaves of C. alata Linn. were extracted using different solvents as follows:water, methanol, ethanol, n-hexane and lastly with acetone. The crude extract was investigated for antifungal and antibacterial activities using disc diffusion method against Coccidioidesimmitis, Exophilia dermatitidis, Aspergillus fumigatus and human pathogenic fungi Candida albicans and a group of bacteria, Staphylococcus aureus. The minimum inhibitory concentrations of the methanolic extract were determined using the agar dilution method. Herbal ointments were prepared by incorporating the methanol extract of C. alata into emulsifying ointment to obtain different concentrations of 25, 50, 100, and 200 mg/mL. Results:The methanol extraction gave the maximum extraction. The formulated C. alata ointment when compared with standard drugs nystatin and streptomycin in vitro was more effective against the microorganisms. Conclusions:This study showed that C. alata had antifungal and antibacterial activities when formulated as ointment for topical use and could, therefore, explained its folkloric use for the treatment of dermatitis.
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