Objective To explore the effect of conservative treatment of gastric ulcer perforation.Methods 156 patients with acute gastric ulcer perforation were randomly divided into conservative treatment group (96 cases) and surgical treatment group (60 cases), conservative treatment group were treated by conservative treatment, surgical treatment group was treated by conservative treatment, to observe and summarize the efifcacy of conservative treatment.Results All of 96 patients in line with the indications of conservative treatment, cured by conservative treatment,there were no obvious complications, no death cases. Whereas, there were 9 cases of anastomotic leakage, abdominal abscess and other complications in the surgical treatment group, 5 cases improved after re operation treatment, while 2 cases died due to multiple organ failure. The complications and cure rate between two groups, the difference was statistically signiifcant (P<0.05).Conclusion The patients of that mild clinical symptoms,no pyloric obstruction and bleeding, peritonitis limitations, exudate is dififcult to draw out or the exudate less than 5mL, to take standardized conservative treatment can achieve the purpose of cure healing.%目的：探讨保守方法治疗胃十二指肠溃疡穿孔的临床疗效。方法选取急性胃十二指肠溃疡穿孔患者156例，分为保守治疗组（n=96）和手术治疗组（n=60），保守治疗组采取保守治疗方法治疗，手术治疗组直接行手术治疗，分析保守方法的临床疗效。结果96例患者均符合保守治疗的适应证，经保守治疗全部痊愈，无明显并发症的发生，无死亡患者；手术治疗组治愈53例，出现吻合口瘘、腹腔脓肿等并发症9例，经再次手术治疗后5例好转，而另有2例因多器官衰竭而死亡。2组患者的并发症及治愈率等比较，差异有统计学意义（P＜0.05）。结论对于临床症状较轻、无幽门梗阻及出血，腹膜炎局限，渗出液难以抽出或少于5 mL的患者采取规范化保守治疗也可以达到治愈的目的，疗效确切。
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