Predictive Values of Postoperative and Dynamic Changes of Inflammation Indexes in Survival of Patients with Resected Colorectal Cancer

Zi-quan ZHOU; Shuo PANG; Xing-chen YU; Qi XUE; Hong-yu JIANG; Xin-jun LIANG; Li LIU

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Predictive Values of Postoperative and Dynamic Changes of Inflammation Indexes in Survival of Patients with Resected Colorectal Cancer

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The aim of the present study was to evaluate the prognostic potential of postoperative scores of inflammation indexes and the dynamic changes of scores before and after tumor resection in colorectal cancer patients.The study included 516 colorectal cancer patients with primary colorectal tumor resection.Cox regression was applied to estimate the associations of postoperative and dynamic changes of inflammation indexes with progression-free survival and overall survival.As results,we found that higher postoperative neutrophil to lymphocyte ratio (NLR),neutrophil and monocyte to lymphocyte ratio (NMLR),platelet to lymphocyte ratio (PLR) and systemic immune inflammation index (SII)were associated with shorter progression-free survival.The increased NLR,NMLR,PLR,SII and C-reaction protein (CRP)to albumin (ALB) ratio (CAR)were associated with poor progression-free survival,with HRs (95% CIs)of 1.92 (1.27-2.90),1.46(1.11-2.09),2.10(1.34-3.30),1.81(1.22-2.70)and 1.65(1.03-2.67), respectively.Postoperative NMLR,SII,CAR,and their dynamic changes were also significantly correlated with overall survival,with the HRs (95% CIs)of 2.63(1.30-3.97), 2.44(1.43-4.17),2.74(1.31-5.74),2.08(1.21-3.60),1.97(1.12-3.45)and 2.55(1.21-5.38)respectively.In conclusion,postoperative inflammation indexes and their dynamic changes,particularly for NMLR,SII and CAR are promising prognostic predictors of CRC patients.

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《当代医学科学(英文)》 |2018年第005期|P.798-808|共11页
作者
Zi-quan ZHOU; Shuo PANG; Xing-chen YU; Qi XUE; Hong-yu JIANG; Xin-jun LIANG; Li LIU;
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作者单位

[1]Department of Epidemiology and Btostatistics,the Ministry of Education Key Lab of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

[1]Department of Epidemiology and Btostatistics,the Ministry of Education Key Lab of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

[1]Department of Epidemiology and Btostatistics,the Ministry of Education Key Lab of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

[1]Department of Epidemiology and Btostatistics,the Ministry of Education Key Lab of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

[1]Department of Epidemiology and Btostatistics,the Ministry of Education Key Lab of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

[2]Department of Medical Oncology,Hubei Cancer Hospital,Wuhan 430079,China;

[1]Department of Epidemiology and Btostatistics,the Ministry of Education Key Lab of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;

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原文格式 PDF
正文语种 CHI
中图分类医药、卫生;
关键词
colorectal cancer; postoperative inflammation index; dynamic change; prognosis;

机译：大肠癌;术后炎症指数;动态变化;预后;

Predictive Values of Postoperative and Dynamic Changes of Inflammation Indexes in Survival of Patients with Resected Colorectal Cancer

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