A Second Dose of GnRHa in Combination with Luteal GnRH Antagonist May Eliminate Ovarian Hyperstimulation Syndrome in Women with≥30 Follicles Measuring≥11 mm in Diameter on Trigger Day and/or Pre-trigger Peak Estradiol Exceeding 10 000 pg/mL

Ling DENG; Xue-Ian LI; De-sheng YE; Christophe Blockeel; Xing-yu ZHOU; Shi-ling CHEN; Xin CHEN

首页> 中文期刊> 《当代医学科学(英文)》 >A Second Dose of GnRHa in Combination with Luteal GnRH Antagonist May Eliminate Ovarian Hyperstimulation Syndrome in Women with≥30 Follicles Measuring≥11 mm in Diameter on Trigger Day and/or Pre-trigger Peak Estradiol Exceeding 10 000 pg/mL

A Second Dose of GnRHa in Combination with Luteal GnRH Antagonist May Eliminate Ovarian Hyperstimulation Syndrome in Women with≥30 Follicles Measuring≥11 mm in Diameter on Trigger Day and/or Pre-trigger Peak Estradiol Exceeding 10 000 pg/mL

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

This observational study included 21 patients at remarkably high risk of ovarian hyperstimulation syndrome(OHSS),characterized by more than 30 follicles measuring≥11 mm in diameter on trigger day and/or pre-trigger peak estradiol exceeding 10 000 pg/mL.which was also the feature of women with established severe early OHSS followed by gonadotrophin-releasing hormone agonist(GnRHa)trigger and freeze-all policy that previously have been reported.All patients received a second dose of GnRHa 12 h after the first GnRHa trigger combined with administration of GnRH antagonist at 0.25 mg/day for a period of 3 days from the day of oocyte retrieval onwards.The in vitro fertilization(IVF)outcomes may be preferable compared with a bolus of GnRHa trigger and none of the included patients developed moderate-to-severe OHSS.Moreover,patients''symptoms,reproductive honnone levels and ultrasound findings were improved significantly.This new strategy seems to be efficacious and could be a further supplement of GnRHa trigger with or without applying freeze-all strategy to completely prevent early-onset moderate to severe OHSS,especially for the patients characterized by≥30 follicles measuring≥11 mm in diameter on trigger day and/or pre-trigger peak estradiol exceeding 10 000 pg/mL.Further studies should be performed to compare this regimen with conventional methods of OHSS prevention.

著录项

来源
《当代医学科学(英文)》 |2019年第2期|P.278-284|共7页
作者
Ling DENG; Xue-Ian LI; De-sheng YE; Christophe Blockeel; Xing-yu ZHOU; Shi-ling CHEN; Xin CHEN;
展开▼
作者单位

[1]Center for Reproductive Medicine;

Department of Gynecology and Obstetrics;

Nanfang Hospital;

Southern Medical University;

Guangzhou 510515;

China;

[1]Center for Reproductive Medicine;

Department of Gynecology and Obstetrics;

Nanfang Hospital;

Southern Medical University;

Guangzhou 510515;

China;

[2]Department of Reproductive Medicine;

Jiangmen Central Hospital;

Jiangmen 529030;

China;

[1]Center for Reproductive Medicine;

Department of Gynecology and Obstetrics;

Nanfang Hospital;

Southern Medical University;

Guangzhou 510515;

China;

[3]Centre for Reproductive Medicine;

Universitair Ziekenhuis Brussel(UZ Brussel);

Laarbeeklaan 101-1090 Brussels;

Belgium;

[1]Center for Reproductive Medicine;

Department of Gynecology and Obstetrics;

Nanfang Hospital;

Southern Medical University;

Guangzhou 510515;

China;

[1]Center for Reproductive Medicine;

Department of Gynecology and Obstetrics;

Nanfang Hospital;

Southern Medical University;

Guangzhou 510515;

China;

[1]Center for Reproductive Medicine;

Department of Gynecology and Obstetrics;

Nanfang Hospital;

Southern Medical University;

Guangzhou 510515;

China;

展开▼
原文格式 PDF
正文语种 CHI
中图分类子宫肿瘤;
关键词
in-vitro fertilization; ovarian hyperstimulation syndrome; GnRH agonist; GnRH antagonist; freeze-all;

机译：体外受精;卵巢过度刺激综合征;GnRH激动剂;GnRH拮抗剂;速冻;

A Second Dose of GnRHa in Combination with Luteal GnRH Antagonist May Eliminate Ovarian Hyperstimulation Syndrome in Women with≥30 Follicles Measuring≥11 mm in Diameter on Trigger Day and/or Pre-trigger Peak Estradiol Exceeding 10 000 pg/mL

摘要

著录项

相关主题

期刊订阅