Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy

Qi-qi WANGI; Ming-xue LI; Chen LI; Xiao-xia GU; Meng-zhu ZHENG; Li-xia CHEN; Hua LI

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Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy

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In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic conditions.Investigation on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the world.In recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential nutrients.Natural products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer drugs.And numerous NPs have been reported to act on cancer energy metabolism targets.Herein,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared.

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《当代医学科学(英文)》 |2020年第2期|P.205-217|共13页
作者
Qi-qi WANGI; Ming-xue LI; Chen LI; Xiao-xia GU; Meng-zhu ZHENG; Li-xia CHEN; Hua LI;
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作者单位

Wuya College of Inovation School of Pharmaceutical Engineering Key Laboratory of Structure-Based Drug Design&Discovery Ministry of Education Shenyang Pharmaceutical Universiry Shenyang 110016 China;

Wuya College of Inovation School of Pharmaceutical Engineering Key Laboratory of Structure-Based Drug Design&Discovery Ministry of Education Shenyang Pharmaceutical Universiry Shenyang 110016 China;

Wuya College of Inovation School of Pharmaceutical Engineering Key Laboratory of Structure-Based Drug Design&Discovery Ministry of Education Shenyang Pharmaceutical Universiry Shenyang 110016 China;

Wuya College of Inovation School of Pharmaceutical Engineering Key Laboratory of Structure-Based Drug Design&Discovery Ministry of Education Shenyang Pharmaceutical Universiry Shenyang 110016 China;

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China;

Wuya College of Inovation School of Pharmaceutical Engineering Key Laboratory of Structure-Based Drug Design&Discovery Ministry of Education Shenyang Pharmaceutical Universiry Shenyang 110016 China;

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
cancer energy metabolism; cancer therapy; natural products; binding targets; inhibitors;

机译：癌症能量代谢;癌症治疗;天然产物;结合靶标;抑制剂;

Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy

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