Bi-level Nasal Positive Airway Pressure(BiPAP)versus Nasal Continuous Positive Airway Pressure(CPAP)for Preterm Infants with Birth Weight Less Than 1500g and Respiratory Distress Syndrome Following INSURE Treatment:A Two-center Randomized Controlled Trial

Rui PAN; Gao-yan CHEN; Jing WANG; Zhao-xian ZHOU; Ping-ying ZHANG; Li-wen CHANG; Zhi-hui RONG

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Bi-level Nasal Positive Airway Pressure(BiPAP)versus Nasal Continuous Positive Airway Pressure(CPAP)for Preterm Infants with Birth Weight Less Than 1500g and Respiratory Distress Syndrome Following INSURE Treatment:A Two-center Randomized Controlled Trial

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The present study aimed to examine the effectiveness of bi-level positive airway pressure(BiPAP)versus continuous positive airway pressure(CPAP)in preterm infants with birth weight less than 1500 g and respiratory distress syndrome(RDS)following intubation-surfactant-extubation(INSURE)treatment.A two-center randomized control trial was performed.The primary outcome was the reintubation rate of infants within 72 h of age after INSURE.Secondary outcomes included bronchopulmonary dysplasia(BPD),necrotizing enterocolitis(NEC),retinopathy of prematurity(ROP)and incidences of adverse events.Lung function at one year of corrected age was also compared between the two groups.There were 140 cases in the CPAP group and 144 in the BiPAP group.After INSURE,the reintubation rates of infants within 72 h of age were 15%and 11.1%in the CPAP group and the BiPAP group,respectively(P>0.05).Neonates in the BiPAP group was on positive airway pressure(PAP)therapy three days less than in the CPAP group(12.6 d and 15.3 d,respectively,P0.05).There was no difference in lung function at one year of age between the two groups(P>0.05).In conclusion,after INSURE,the reintubation rate of infants within 72 h of age was comparable between the BiPAP group and the CPAP group.BiPAP was superior to CPAP in terms of shorter durations(days)on PAP support and oxygen supplementation.There were no differences in the incidences of BPD and ROP,and lung function at one year of age between the two ventilation methods.

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《当代医学科学(英文)》 |2021年第3期|P.542-547|共6页
作者
Rui PAN; Gao-yan CHEN; Jing WANG; Zhao-xian ZHOU; Ping-ying ZHANG; Li-wen CHANG; Zhi-hui RONG;
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作者单位

Department of Pediatrics Xicmgyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science Xiangyang 440021 China;

Department of Pediatrics Xicmgyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science Xiangyang 440021 China;

Department of Neonatology Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 China;

Department of Neonatology Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 China;

Department of Pediatrics Xicmgyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science Xiangyang 440021 China;

Department of Neonatology Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 China;

Department of Neonatology Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 China;

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原文格式 PDF
正文语种 chi
中图分类儿科学;
关键词
noninvasive ventilator; neonate; bronchopulmonary dysplasia; continuous positive airway pressure;

Bi-level Nasal Positive Airway Pressure(BiPAP)versus Nasal Continuous Positive Airway Pressure(CPAP)for Preterm Infants with Birth Weight Less Than 1500g and Respiratory Distress Syndrome Following INSURE Treatment:A Two-center Randomized Controlled Trial

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