Neutralization activity of influenza A virus humanized antibodies against new subtypes of influenza viruses

Liu Jing; Wang Tiecheng; Xie Ying; Li Yuanguo; He Jian; Zhang Xinghai; Sun Weiyang; Feng Na; Qin Chuan; Gao Yuwei; Xia Xianzhu

首页> 中文期刊> 《生物安全与健康（英文）》 >Neutralization activity of influenza A virus humanized antibodies against new subtypes of influenza viruses

Neutralization activity of influenza A virus humanized antibodies against new subtypes of influenza viruses

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Antibodies are ideal for controlling the influenza A virus, but their effect on newly emerging strains is unclear. Here, we assessed the neutralization activity of the humanized monoclonal antibodies （mAbs） F10, H98 and H40 against circulating influenza viruses （H5N1, H1N1, H3N2 and H7N7 and new subtypes viruses H5N6 and H7N9）. The results showed that all the three humanized mAbs （F10, H98 and H40） displayed different degrees of virus neutralization activities when encountered with different subtypes of influenza viruses. Remarkably, the humanized monoclonal antibody F10 produced higher and broader neutralization titers （range 25–1.56 μg/ml） than those of the other two humanized mAbs （H98 （range 50–3.12 μg/ml）, H40 （range 50–5.56 μg/ml）） to against the viruses H5N1, H1N1, H3N2, H7N7, H5N6 and H7N9. This mAb may represent a new class of heterosubtypic neutralizing humanized mAb that could replace vaccines and chemical drugs.

著录项

来源
《生物安全与健康（英文）》 |2019年第3期||共页
作者
Liu Jing; Wang Tiecheng; Xie Ying; Li Yuanguo; He Jian; Zhang Xinghai; Sun Weiyang; Feng Na; Qin Chuan; Gao Yuwei; Xia Xianzhu;
展开▼
作者单位

1. Comparative Medicine Center 2. Peking Union Medical College (PUMC) and Institute of Laboratory Animal Sciences 3. Chinese Academy of Medical Sciences (CAMS) 4. Beijing 100021 5. China 6. Key Laboratory of Jilin Province for Zoonosis 7. Institute of Mi;

展开▼
原文格式 PDF
正文语种 chi
中图分类流行性感冒;
关键词
Influenza A virus humanized antibodies; Neutralization activity; New subtypes of influenza viruses;

相似文献

中文文献
外文文献
专利

Neutralization activity of influenza A virus humanized antibodies against new subtypes of influenza viruses

摘要

著录项

相似文献

相关主题

期刊订阅