This paper aims to study low dimensional cohomology of Hom-Lie algebras and the qdeformed W(2, 2) algebra. We show that the q-deformed W(2, 2) algebra is a Hom-Lie algebra. Also,we establish a one-to-one correspondence between the equivalence classes of one-dimensional central extensions of a Hom-Lie algebra and its second cohomology group, leading us to determine the second cohomology group of the q-deformed W(2, 2) algebra. In addition, we generalize some results of derivations of finitely generated Lie algebras with values in graded modules to Hom-Lie algebras.As application, we compute all αk-derivations and in particular the first cohomology group of the q-deformed W(2, 2) algebra.
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