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首页> 中文期刊> 《肠胃病学期刊（英文）》 >Spontaneous Bacterial Peritonitis and Short-Term Prognosis in a Group of Decompensated Cirrhotic Patients in Yaounde: A Cross-Sectional Study

Spontaneous Bacterial Peritonitis and Short-Term Prognosis in a Group of Decompensated Cirrhotic Patients in Yaounde: A Cross-Sectional Study

         
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摘要

Introduction: Spontaneous bacterial peritonitis (SBP) is among the most common infections in cirrhotic patients. Data on SBP are rare in Cameroon. This prompted us to carry out this study on patients with decompensated cirrhosis of the liver in Yaounde University Hospital Centre (YUHC). Methods: We carried out a cross-sectional study from December 2015 to June 2016 in three units of YUHC. All patients with decompensated liver cirrhosis were included. Our sampling was consecutive. Diagnosis of cirrhosis was performed, based on clinical, biological and ultrasound criteria. A neutrophil count greater than 250 cell/mm3 in ascites fluid defined an SBP. Data on socio-demography, clinical presentation, and outcomes were collected. Results: We included 34 decompensated cirrhotic patients (15 males). Patients mean age was 57.5 ± 2 years (SBP positive: 48.7 ± 21.3 versus without SBP: 59.8 ± 19.5, p = 0.22). SBP diagnosis was made in 6 (17.7%) patients. Compared to patients with decompensated liver cirrhosis and without SBP, positive SBP patients had a higher pulse rate (p = 0.002) and respiratory rate (p = 0.02). The patients with SBP were more likely to present these other clinical features: pulse rate >100 (RR: 4.2, [95% CI: 0.7 - 27.7];p = 0.02), presence of jaundice (RR: 3.4, [95% CI: 0.6 - 21.1];p = 0.09), being from female gender (RR: 3.2, [95% CI: 0.5 - 19.9]; p = 0.11), advanced liver disease (Child C class) (RR: 2.4, [95% CI: 0.4 - 14.5], p = 0.66), low-plasma albumin (less than 20 g/L) (RR: 1.7, [95% CI: 0.8 - 3.9], p = 0.08), respiratory rate > 30 (RR: 1.6, [95% CI: 0.6 - 3.3], p = 0.05) and fever/hypothermia (RR: 1.5, [95% CI: 0.6 - 3.4];p = 0.22). Evolution after a 72-hours antibiotherapy was stationary in four cases and unfavorable in two patients, resulting in death. Conclusion: SBP prevalence was 17.7%. SBP patients were younger, from female sex, tachycardia and polypnea, presenting with fever/hypothermia and signs of advanced liver disease than non-SBP patients. Improvement of our technical platform will be useful to determine the cause of cirrhosis and identify the different germs responsible for SBP.

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  • 来源
    《肠胃病学期刊（英文）》 |2020年第8期|P.203-213|共11页
  • 作者

    Mathurin Pierre Kowo; Sylvain Raoul Simeni Njonnou; Nelly Karelle Weyou Noubissi; Firmin Ankouane Andoulo; Gabin Ulrich Kenfack; Larissa Pessidjo Djomatcho; Hortense Gonsu Kamga; Bernadette Ngo Nonga;

  • 作者单位

    Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde CameroonYaounde University Teaching Hospital Yaounde Cameroon;

    Department of Internal Medicine and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon;

    Higher Institute of Medical Technology Yaounde Cameroon;

    Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde CameroonYaounde University Teaching Hospital Yaounde Cameroon;

    Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon;

    Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon;

    Yaounde University Teaching Hospital Yaounde CameroonDepartment of Microbiology Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon;

    Yaounde University Teaching Hospital Yaounde CameroonDepartment of Surgery Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 消化系及腹部疾病;
  • 关键词

    Spontaneous Bacterial Peritonitis; Decompensated Liver Cirrhosis; Sub-Saharan Africa;

    机译：自发性细菌性腹膜炎;代偿性肝硬化;撒哈拉以南非洲;
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