Effects of Teriparatide and Aerobic Exercise on Lumbar Spine Microstructure in Ovariectomized and Tail-Suspended Rats

Chiaki Sato; Naohisa Miyakoshi; Yuji Kasukawa; Koji Nozaka; Hiroyuki Tsuchie; Itsuki Nagahata; Yusuke Yuasa; Kazunobu Abe; Hikaru Saito; Ryo Shoji; Yoichi Shimada

首页> 中文期刊> 《矫形学期刊（英文）》 >Effects of Teriparatide and Aerobic Exercise on Lumbar Spine Microstructure in Ovariectomized and Tail-Suspended Rats

Effects of Teriparatide and Aerobic Exercise on Lumbar Spine Microstructure in Ovariectomized and Tail-Suspended Rats

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Osteoporosis is an increasingly prevalent malady of the elderly that is associated with bone fragility and increased risk of fractures. Osteoporosis treatments focus on restoring bone strength and quality. Teriparatide (TPTD) is a therapeutic agent that has been shown to increase bone strength by improving the volume and connectivity of trabecular bone. Exercise is also known to have pro-osteogenic effects. Here we used a rat model of severe osteoporosis (ovariectomized and tail-suspension) to evaluate the effects of TPTD, exercise and a combination of TPTD and exercise on the microstructure of trabecular bone. TPTD mono-therapy and TPTD combined with exercise treatment significantly increased bone mineral density (BMD) in the whole body. Micro-computed tomography analysis revealed that a combination of exercise and TPTD treatment significantly decreased bone surface to volume and trabecular separation compared with those of the control and exercise groups. Node-strut analysis indicated that exercise or TPTD alone did not affect trabecular bone connectivity. However, the combination of exercise and TPTD treatment significantly decreased measures of trabecular bone connectivity (node number) that are consistent with a transition from rod-like to plate-like of trabecular bone microstructures. The combination treatment with exercise and TPTD improved microstructure of trabecular bone in the OVX and tail-suspended rats. These results indicate that combining exercise with TPTD represents a viable means to improve cancellous bone strength in osteoporosis populations.

著录项

来源
《矫形学期刊（英文）》 |2021年第1期|P.1-11|共11页
作者
Chiaki Sato; Naohisa Miyakoshi; Yuji Kasukawa; Koji Nozaka; Hiroyuki Tsuchie; Itsuki Nagahata; Yusuke Yuasa; Kazunobu Abe; Hikaru Saito; Ryo Shoji; Yoichi Shimada;
展开▼
作者单位

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan;

展开▼
原文格式 PDF
正文语种 chi
中图分类内分泌腺疾病及代谢病;
关键词
Teriparatide; Aerobic Exercise; Micro Structure; Cancellous Bone;

机译：Teriparatide;有氧运动;微结构;松质骨骼;

Effects of Teriparatide and Aerobic Exercise on Lumbar Spine Microstructure in Ovariectomized and Tail-Suspended Rats

摘要

著录项

相关主题

期刊订阅