Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Obsessive-Compulsive Disorder in a Japanese Population

Takeyuki Akimoto; Chihiro Sutoh; Masaru Kuno; Daisuke Matsuzawa; Tomihisa Niitsu; Masaomi Iyo; Eiji Shimizu

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Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Obsessive-Compulsive Disorder in a Japanese Population

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A role of lower brain-derived neurotrophic factor (BDNF) content in the pathogenesis of several mental illnesses has been suggested, especially in major depression. It is not known whether BDNF is involved in the pathogenesis of obsessive-compulsive disorder (OCD). Herein, we assessed the serum BDNF content and its correlation with symptom severity in a Japanese population with OCD. The serum BDNF levels of OCD patients (n = 39) and healthy controls (n = 37) were measured by ELISA. The severity of OCD symptoms was assessed by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Beck Depression Inventory (BDI). The OCD patients’ BDNF levels were significantly higher than those of the controls (17.5 ± 7.3 vs. 12.7 ± 4.7) (p < 0.01). No correlation was observed between the OCD patients’ BDNF levels and their OCD symptoms as scored by the Y-BOCS. For all 76 subjects, the BDI scores were significantly negatively correlated with the serum BDNF levels. Our findings revealed that contrary to previous reports, the serum BDNF content in OCD patients could be higher than that of healthy subjects.

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《精神病学期刊（英文）》 |2021年第1期|P.20-28|共9页
作者
Takeyuki Akimoto; Chihiro Sutoh; Masaru Kuno; Daisuke Matsuzawa; Tomihisa Niitsu; Masaomi Iyo; Eiji Shimizu;
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作者单位

Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan;

Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan;

Research Center for Child Mental Development Chiba University Chiba Japan;

Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba JapanResearch Center for Child Mental Development Chiba University Chiba Japan;

Department of Psychiatry Graduate School of Medicine Chiba University Chiba Japan;

Department of Psychiatry Graduate School of Medicine Chiba University Chiba Japan;

Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba JapanResearch Center for Child Mental Development Chiba University Chiba Japan;

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正文语种 chi
中图分类神经病学与精神病学;
关键词
Brain-Derived Neurotropic Factor (BDNF); Obsessive-Compulsive Disorder (OCD); ELISA; Depression;

机译：脑衍生的神经促症因子（BDNF）;强迫症（OCD）;ELISA;抑郁症;

Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Obsessive-Compulsive Disorder in a Japanese Population

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