Preventing Implant Bacterial Infections with Interconnected 3D Porous Structures (I3D)— A Proof-of-Concept Study

Steven Guo; Alexandria Ramos; Zhongqiang Li; Hong Yao; Jian Xu; Shaomian Yao

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Preventing Implant Bacterial Infections with Interconnected 3D Porous Structures (I3D)— A Proof-of-Concept Study

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Oral antibiotics are often prescribed to prevent infection after implant surgery;however, only a small fraction of the antibiotics can reach the implants. Thus, there are concerns about overusing antibiotics. We designed and fabricated porous implants with interconnecting 3D structures (I3D) and hypothesized that such I3D structures could serve as a depository for antimicrobial agents to prevent infection locally. The implants were either treated with antibiotics or coated with silver nanoparticles (AgNPs) by electrodeposition to test this hypothesis. The antimicrobial assay was conducted, and bacterial growth zones of inhibition (ZOIs) were monitored. Overall, I3D implants resulted in larger ZOIs than did the solid implants, and the center I3D (cI3D)-implant produced the largest ZOI. In the antibiotic treatment testing, the diameters of ZOIs of the solid implant vs. I3D implant were about 14 mm vs. 15 to 18 mm on day 2;however, the diameter quickly reduced to 9 mm on day 3 and 5 mm on days 6 and 8 for the solid implant, while no obvious change of the zone was seen for I3D implants. For the AgNPs coated implants, the ZOIs for the I3D implants were generally greater than the solid implant over four weeks of incubation. A significantly larger ZOI (~1 - 2 mm larger on average) was seen for AgNPs coated I3D implants at 0.1 V - 0.01 M, 0.3 V - 0.01 M, and 1.5 V - 0.01 M treatments compared to AgNPs coated solid implants. Given that we have previously shown that I3D implants can reserve chemoattractants to recruit stem cells to enhance osseointegration, we conclude that implants with the I3D structures could be beneficial not only for osseointegration but also in preventing infection.

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《生物科学与医学（英文）》 |2021年第1期|P.16-29|共14页
作者
Steven Guo; Alexandria Ramos; Zhongqiang Li; Hong Yao; Jian Xu; Shaomian Yao;
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作者单位

Comparative Biomedical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA USADepartment of Biomedical Engineering Johns Hopkins University Baltimore MD USA;

Comparative Biomedical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA USA;

Division of Electrical and Computer Engineering College of Engineering Louisiana State University Baton Rouge LA USA;

Department of Mechanical and Industrial Engineering Louisiana State University Baton Rouge LA USA;

Division of Electrical and Computer Engineering College of Engineering Louisiana State University Baton Rouge LA USA;

Comparative Biomedical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA USA;

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原文格式 PDF
正文语种 chi
中图分类金属学与热处理;
关键词
Dental Implant; Antimicrobial Agents; Peri-Implantitis; Silver Nanoparticles; 3D-Printing;

机译：牙科植入物;抗微生物剂;Peri-植入炎;银纳米粒子;3D印刷;

Preventing Implant Bacterial Infections with Interconnected 3D Porous Structures (I3D)— A Proof-of-Concept Study

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