Biological function of Presenilin and its role in AD pathogenesis

Shuting Zhang; Mingming Zhang; Fang Cai; Weihong Song

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Biological function of Presenilin and its role in AD pathogenesis

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Presenilins(PSs)are the catalytic core of γ-secretase complex.However,the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive.Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components–presenilins and their biological functions and contributions to the AD pathogenesis.The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones.The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch;the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway,regulating calcium homeostasis and their interaction with synaptic transmission.

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《转化神经变性病(英文)》 |2013年第1期|P.95-107|共13页
作者
Shuting Zhang; Mingming Zhang; Fang Cai; Weihong Song;
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作者单位

Townsend Family Laboratories Department of Psychiatry Brain Research Center Graduate Program in Neuroscience The University of British Columbia 2255 Wesbrook Mall Vancouver BC V6T 1Z3 Canada;

Townsend Family Laboratories Department of Psychiatry Brain Research Center Graduate Program in Neuroscience The University of British Columbia 2255 Wesbrook Mall Vancouver BC V6T 1Z3 Canada;

Townsend Family Laboratories Department of Psychiatry Brain Research Center Graduate Program in Neuroscience The University of British Columbia 2255 Wesbrook Mall Vancouver BC V6T 1Z3 Canada;

Townsend Family Laboratories Department of Psychiatry Brain Research Center Graduate Program in Neuroscience The University of British Columbia 2255 Wesbrook Mall Vancouver BC V6T 1Z3 Canada;

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正文语种 chi
中图分类物理化学（理论化学）、化学物理学;
关键词
complex.; function; cleavage;

Biological function of Presenilin and its role in AD pathogenesis

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