Neurodegenerative changes initiated by presynaptic dysfunction

Toru Yasuda; Yasuto Nakata; Chi-Jing Choong; Hideki Mochizuki

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Neurodegenerative changes initiated by presynaptic dysfunction

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α-Synucleinopathies are a subgroup of neurodegenerative diseases including dementia with Lewy bodies(DLB)and Parkinson’s disease(PD).Pathologically,these disorders can be characterized by the presence of intraneuronal aggregates composed mainly of α-synuclein(αSyn),which are called Lewy bodies and Lewy neurites.Recent report showed that more than 90% of αSyn aggregates are present in the form of very small deposits in presynaptic terminals of the affected neurons in DLB.However,the mechanisms responsible for presynaptic accumulation of abnormal αSyn remain unclear.In this article,we review recent findings on the involvement of presynaptic dysfunction in the initiation of neuronal dysfunctional changes.This review highlights that the presynaptic failure can be a potential trigger of the dying-back neuronal death in neurodegenerative diseases.

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《转化神经变性病(英文)》 |2013年第1期|P.108-112|共5页
作者
Toru Yasuda; Yasuto Nakata; Chi-Jing Choong; Hideki Mochizuki;
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Department of Neurology Osaka University Graduate School of Medicine Suita Osaka JapanPresent address:Department of Genetics National Center for Child Health and Development Setagaya-ku Tokyo Japan;

Department of Neurology Osaka University Graduate School of Medicine Suita Osaka Japan;

Department of Neurology Osaka University Graduate School of Medicine Suita Osaka Japan;

Department of Neurology Osaka University Graduate School of Medicine Suita Osaka Japan;

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中图分类神经病学与精神病学;
关键词
degenerative; dysfunction; involvement;

Neurodegenerative changes initiated by presynaptic dysfunction

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