Evidence of neurodegeneration in autism spectrum disorder

Janet K Kern; David A Geier; Lisa K Sykes; Mark R Geier

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Evidence of neurodegeneration in autism spectrum disorder

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Autism spectrum disorder(ASD)is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and abilities.Loss of neurological function in ASD,as observed in affected children who have regressed,can be explained as neurodegeneration.Although there is research evidence of neurodegeneration or progressive encephalopathy in ASD,the issue of neurodegeneration in ASD is still under debate.Evidence of neurodegeneration in the brain in ASD includes:(1)neuronal cell loss,(2)activated microglia and astrocytes,(3)proinflammatory cytokines,(4)oxidative stress,and(5)elevated 8-oxo-guanosine levels.The evidence from this review suggests that neurodegeneration underlies the loss of neurological function in children with ASD who have experienced regression and loss of previously acquired skills and abilities,and that research into treatments to address the issue of neurodegeneration in ASD are warranted.

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《转化神经变性病(英文)》 |2013年第1期|P.113-118|共6页
作者
Janet K Kern; David A Geier; Lisa K Sykes; Mark R Geier;
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作者单位

Institute of Chronic Illnesses Incorporation Silver Spring MD USAUniversity of Texas Southwestern Medical Center at Dallas Dallas TX USA;

Institute of Chronic Illnesses Incorporation Silver Spring MD USA;

CoMeD Incorporation Silver Spring MD USA;

Institute of Chronic Illnesses Incorporation Silver Spring MD USA;

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正文语种 chi
中图分类心脏、血管（循环系）疾病;
关键词
Autism spectrum disorder(ASD); Autism; Neurodegeneration; Regression; Neuronal cell loss; Microglia; Oxidative stress; Cytokines;

Evidence of neurodegeneration in autism spectrum disorder

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