首页> 中文期刊> 《转化神经变性病(英文)》 >Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

         

摘要

The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.

著录项

  • 来源
    《转化神经变性病(英文)》 |2013年第1期|P.134-142|共9页
  • 作者单位

    Centre for Healthy Brain Ageing School of Psychiatry University of New South Wales Sydney AustraliaAged Care and Rehabilitation Bankstown-Lidcombe Hospital Sydney Australia;

    Department of Human Physiology and Centre for Neuroscience Flinders University School of Medicine Adelaide Australia;

    Aged Care and Rehabilitation Bankstown-Lidcombe Hospital Sydney AustraliaFaculty of Medicine University of New South Wales Sydney Australia;

    Centre for Healthy Brain Ageing School of Psychiatry University of New South Wales Sydney AustraliaNeuropsychiatric Institute Prince of Wales Hospital Sydney Australia;

    School of Medical Sciences University of New South Wales Sydney AustraliaSt Vincent’s Centre for Applied Medical Research Sydney Australia;

    St George Clinical School University of New South Wales and St George Hospital Sydney Australia;

    School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney Australia;

    School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney Australia;

    St George Clinical School University of New South Wales and St George Hospital Sydney Australia;

    St George Clinical School University of New South Wales and St George Hospital Sydney Australia;

    Aged Care and Rehabilitation Bankstown-Lidcombe Hospital Sydney AustraliaDepartment of Human Physiology and Centre for Neuroscience Flinders University School of Medicine Adelaide AustraliaAged Care and Rehabilitation Unit Bankstown-Lidcombe Hospital Eldridge Road Bankstown 2031 NSW Australia;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    Alpha-synuclein; Neurons; Astrocytes; Fibroblasts; Mitochondria;

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