What does complement do in Alzheimer’s disease? Old molecules with new insights

Yong Shen; Libang Yang; Rena Li

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What does complement do in Alzheimer’s disease? Old molecules with new insights

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Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease(AD)and anti-inflammatory and immunotherapeutic approaches may be amenable to AD treatment.It is known that complement activation occurs in the brain of patients with AD,and contributes to a local inflammatory state development which is correlated with cognitive impairment.In addition to the complement’s critical role in the innate immune system recognizing and killing,or targeting for destruction,complement proteins can also interact with cell surface receptors to promote a local inflammatory response and contributes to the protection and healing of the host.On the other hand,complement activation also causes inflammation and cell damage as an essential immune function to eliminate cell debris and potentially toxic protein aggregates.It is the balance of these seemingly competing events that influences the ultimate state of neuronal function.Our mini review will be focusing on the unique molecular interactions happening in the AD development,the functional outcomes of those interactions,as well as the contribution of each element to AD.

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《转化神经变性病(英文)》 |2013年第1期|P.143-153|共11页
作者
Yong Shen; Libang Yang; Rena Li;
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作者单位

Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute 2040 Whitfield Avenue Sarasota USADepartment of Neurology College of Medicine University of Florida Gainesville FL 32610 USA;

Department of Pediatrics School of Medicine University of Minnesota Minneapolis MN 55455 USA;

Center for Hormones Advanced Science and Education Roskamp Institute 2040 Whitfield Avenue Sarasota Florida USA;

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原文格式 PDF
正文语种 chi
中图分类神经病学与精神病学;
关键词
Alzheimer; healing; inflammation;

What does complement do in Alzheimer’s disease? Old molecules with new insights

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