Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease

G.Du; P.Zhuang; M.Hallett; Y.-Q.Zhang; J.-Y.Li; Y.-J.Li

首页> 中文期刊> 《转化神经变性病(英文)》 >Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease

Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Background:The cardinal features of Parkinson’s disease(PD)are bradykinesia,rigidity and rest tremor.Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms.This study aims to characterize properties of oscillatory activity in the basal ganglia and motor thalamus in patients with PD.Methods:Twenty-nine patients with PD who underwent bilateral or unilateral electrode implantation for subthalamic nucleus(STN)DBS(n=11),unilateral pallidotomy(n=9)and unilateral thalamotomy(n=9)were studied.Microelectrode recordings in the STN,globus pallidus internus(GPi)and ventral oral posterior/ventral intermediate of thalamus(Vop/Vim)were performed.Electromyography of the contralateral limbs was recorded.Single unit characteristics including interspike intervals were analyzed.Spectral and coherence analyses were assessed.Mean spontaneous firing rate(MSFR)of neurons was calculated.Analysis of variance and χ^(2) test were performed.Results:Of 76 STN neurons,39.5% were 4–6 Hz band oscillatory neurons and 28.9% were β frequency band(βFB)oscillatory neurons.The MSFR was 44.2±7.6 Hz.Of 62 GPi neurons,37.1% were 4–6 Hz band oscillatory neurons and 27.4% were βFB neurons.The MSFR was 80.9±9.6 Hz.Of 44 Vop neurons,65.9% were 4–6 Hz band oscillatory neurons and 9%were βFB neurons.The MSFR was 24.4±4.2 Hz.Of 30 Vim oscillatory neurons,70% were 4–6 Hz band oscillatory neurons and 13.3% were β FB neurons.The MSFR was 30.3±3.6 Hz.Further analysis indicated that proportion of βFB oscillatory neurons in STN and GPi was higher than that of similar neurons in the Vop and Vim(P<0.05).Conversely,the proportion of 4–6 Hz band oscillatory neurons and tremor related neurons in the Vim and Vop was higher than that of STN and GPi(P<0.05).The highest MSFR was for GPi oscillatory neurons whereas the lowest MSFR was for Vop oscillatory neurons(P<0.005).Conclusion:The alterations in neuronal activity in basal ganglia play a critical role in generation of parkinsonism.β oscillatory activity is more prominent in basal ganglia than in thalamus suggesting that the activity likely results from dopaminergic depletion.While both basal ganglia and thalamus have tremor activity,the thalamus appears to play a more important role in tremor production,and basal ganglia β oscillatory activity might be the trigger.

著录项

来源
《转化神经变性病(英文)》 |2018年第1期|P.154-166|共13页
作者
G.Du; P.Zhuang; M.Hallett; Y.-Q.Zhang; J.-Y.Li; Y.-J.Li;
展开▼
作者单位

Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University No.45 Changchun Street Xicheng District Beijing 100053 China;

Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University No.45 Changchun Street Xicheng District Beijing 100053 ChinaCenter of Parkinson’s disease Beijing Institute for Brain Disorders Beijing ChinaKey Laboratory of Neurodegenerative Diseases(Capital Medical University) Ministry of Education Beijing China;

Human Motor Control Section Medical Neurology Branch NINDS NIH Bethesda MD USA;

Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University No.45 Changchun Street Xicheng District Beijing 100053 China;

Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University No.45 Changchun Street Xicheng District Beijing 100053 China;

Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University No.45 Changchun Street Xicheng District Beijing 100053 China;

展开▼
原文格式 PDF
正文语种 chi
中图分类数学分析;
关键词
Parkinson’s disease; Basal ganglia; The subthalamic nucleus; The globus pallidus internus; The ventrolateral thalamus; Oscillatory activity; Microelectrode recordings;

Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease

摘要

著录项

相关主题

期刊订阅