Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model

Hans-Peter Müller; David Brenner; Francesco Roselli; Diana Wiesner; Alireza Abaei; Martin Gorges; Karin M.Danzer; Albert C.Ludolph; William Tsao; Philip C.Wong; Volker Rasche; Jochen H.Weishaupt; Jan Kassubek

首页> 中文期刊> 《转化神经变性病(英文)》 >Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model

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Background:In vivo diffusion tensor imaging(DTI)of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis(ALS).Methods:Ten mice with TDP-43^(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type(wt)underwent longitudinal DTI scans at 11.7 T,including one baseline and one follow-up scan with an interval of about 5months.Whole brain-based spatial statistics(WBSS)of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43^(G298S) mice compared to wt at the cohort level.Results were supplemented by tractwise fractional anisotropy statistics(TFAS)and histological evaluation of motor cortex for signs of neuronal loss.Results:Alterations at the cohort level in TDP-43^(G298S) mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal tract.Neuronal loss in layer V of motor cortex was detected in TDP-43^(G298S) at the later(but not at the earlier)timepoint compared to wt.Conclusion:DTI mapping of TDP-43^(G298S) mice demonstrated progression in motor areas M1/M2.WBSS and TFAS are useful techniques to localize TDP-43^(G298S) associated alterations over time in this ALS mouse model,as a biological marker.

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《转化神经变性病(英文)》 |2019年第1期|P.333-345|共13页
作者
Hans-Peter Müller; David Brenner; Francesco Roselli; Diana Wiesner; Alireza Abaei; Martin Gorges; Karin M.Danzer; Albert C.Ludolph; William Tsao; Philip C.Wong; Volker Rasche; Jochen H.Weishaupt; Jan Kassubek;
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Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm GermanyGerman Center for Neurodegenerative Diseases(DZNE) Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

Core Facility Small Animal MRI University of Ulm Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

Department of Pathology The Johns Hopkins University School of Medicine Baltimore USA;

Department of Pathology The Johns Hopkins University School of Medicine Baltimore USA;

Core Facility Small Animal MRI University of Ulm Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

Department of Neurology University of Ulm Oberer Eselsberg 45 RKU D-89081 Ulm Germany;

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正文语种 chi
中图分类神经病学与精神病学;
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Diffusion tensor imaging; Amyotrophic lateral sclerosis; Mutant TDP-43; Fiber tracking; Mouse brain;

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model

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