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首页> 中文期刊> 《美国分子生物学期刊（英文）》 >Bax promoter G(-248)A polymorphism in a Turkish clinical breast cancer patients: A case-control study

Bax promoter G(-248)A polymorphism in a Turkish clinical breast cancer patients: A case-control study

         
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摘要

Bax is an important protein involved in apoptotic process. Mutations of the Bax gene are known to af- fect protein expression and function. A promotor polymorphism G(-248)A in the 5’UTR of Bax gene may alter regulation of apoptosis in carcinogenesis. Our study was performed to test the association be- tween G(-248)A polymorphisms in the Bax gene and breast cancer risk and progression. G(-248)A poly- morphism was genotyped in a Turkish breast cancer, case-control population including 53 female cancer patients (mean age ± SD: 60.9 ± 11.9 years) and 82 controls (mean age ± SD: 57.2 ± 17.5 years) using PCR-RFLP analysis. Genotype and allele frequencies were assessed with the chi-square test. There was no difference in the distribution of Bax genotypes, and allele frequencies were G (87.7% versus 88.4%) and A (12.3% versus 11.6%) in the cancer patients and controls, respectively. Within the cancer group, the presence of a polymorphic Bax G(-248)A allele was not associated with clinico-pathological parameters such as advanced tumor stage, lymph node or distant metastasis. We present the first to report on Bax G(-248)A polymorphisms in breast cancer. Our re- sults suggest that Bax G(-248)A polymorphism do not modify individual susceptibility to invasive breast cancer in Turkish women.

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