Cyclosporin A solid dispersion particles containing lactose, pregelatinized starch and microcrystalline cellulose respectively were prepared by wet granulation method. The hygroscopic behavior, bulk density and angle of repose of these particles were investigated. The results showed that the three fillers could increase the bulk density and flowability. The critical relative humidity for the particles with or without lactose was about 82%.
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机译：（54）标题：具有硅酸盐涂层的固体颗粒（54）：FESTKoRPERPARTKEL MIT SILKATBESCHICHTUNG（57）摘要：本发明涉及一种具有二氧化硅涂层的固体颗粒的生产方法，其包括以下步骤：将固体颗粒分散为将其涂覆在水性介质中以产生固体颗粒分散体，通过缓冲系统调节固体颗粒分散体的pH以产生缓冲的固体颗粒分散体，并向缓冲的固体颗粒分散体中添加碱性硅酸盐溶液以形成二氧化硅在涂覆期间将其涂覆在固体颗粒上，其中选择缓冲体系和碱性硅酸盐溶液的量，使得在添加碱性硅酸盐溶液之前和在添加完成之后，缓冲的固体颗粒分散体的pH至少为7.0。碱性硅酸盐溶液的最大含量为11.0。固体颗粒优选是无机固体，特别是
