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《中国组织工程研究》
>Evaluation of improved quality of life and therapeutic effect of duragesic on cancerous pain in patients with and advanced tumors
Evaluation of improved quality of life and therapeutic effect of duragesic on cancerous pain in patients with and advanced tumors
Objective To investigate therapeutic effect of duragesic in the treatment of cancerous pain in patients with advanced tumors,Method Before entering the study,all patients suffered from moderate to sever cancerous pain,All patients were given 5 doses of duragesic within 15 days,Evaluation was performed every 12 hous,We assessed pain intensity and pain relief by using numoral rating scale(NRS).Quality of life was also evaluated.Result Eventual dose was 2.5 mg in 10cases,5 mg in 49 cases.,7.5 mg in 5 cases,10 mg in 3cases,and 12.5 mg in 1 cases,15mg in 1 case complete relief was observed in 13 cases,partial relief observed in 45 cases, effective rate was 84.06%,The therapeutic effect of duragesic was similar to that of MS contin,Therapeutic dffect occurred 48-72house later and became most significant 2-4 days later,and maintain at constant level,Conclusion By the special pattern for delivery via transdermal system,duragesic produces lasting and stable analgesic effect,In addition,it is characterized by simple operation,convenient application,insignificant adverse .Hence,duragesic can replace oral strong opiod drugs.
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机译：Rationale, design and conduct of a randomised controlled trial evaluating a primary care-based complex intervention to improve the quality of life of heart failure patients: HICman (Heidelberg Integrated Case management)
