Gastrectomy impact on the gut microbiome in patients with gastric cancer:A comprehensive review

Vaidota Maksimaityte; Augustinas Bausys; Marius Kryzauskas; Martynas Luksta; Ieva Stundiene; Klaudija Bickaite; Bernardas Bausys; Tomas Poskus; Rimantas Bausys; Kestutis Strupas

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Gastrectomy impact on the gut microbiome in patients with gastric cancer:A comprehensive review

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Gastric cancer is one of the most common malignancies worldwide and gastrectomy remains the only potentially curative treatment option for this disease.However,the surgery leads to significant physiological and anatomical changes in the gastrointestinal(GI)tract including loss of the gastric barrier,an increase in oxygenation levels in the distal gut,and biliary diversion after gastrectomy.These changes in the GI tract influence the composition of the gut microbiome and thus,host health.Gastrectomy-induced dysbiosis is characterized by increased abundance of typical oral cavity bacteria,an increase in aero-tolerant bacteria(aerobes/facultative anaerobes),and increased abundance of bile acidtransforming bacteria.Furthermore,this dysbiosis is linked to intestinal inflammation,small intestinal bacterial overgrowth,various GI symptoms,and an increased risk of colorectal cancer.

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《世界胃肠外科杂志：英文版（电子版）》 |2021年第7期|678-688|共11页
作者
Vaidota Maksimaityte; Augustinas Bausys; Marius Kryzauskas; Martynas Luksta; Ieva Stundiene; Klaudija Bickaite; Bernardas Bausys; Tomas Poskus; Rimantas Bausys; Kestutis Strupas;
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作者单位

Clinic of Gastroenterology;

Nephrourology;

and Surgery;

Institute of Clinical Medicine;

Faculty of Medicine;

Vilnius University;

Vilnius 03101;

Lithuania;

Department of Abdominal Surgery and Oncology;

National Cancer Institute;

Vilnius 08660;

Lithuania;

Faculty of Medicine;

Vilnius University;

ilnius 03101;

Lithuania;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Gut microbiota; Dysbiosis; Gastric cancer; Gastrectomy; Microbiome; Comprehensive review;

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Gastrectomy impact on the gut microbiome in patients with gastric cancer:A comprehensive review

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