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《中国组织工程研究》
>Effect of regulatory factor of cell cycle p27^kipl and cyclinE proteins on the genesis and progression of human pancreatic cancer
Effect of regulatory factor of cell cycle p27^kipl and cyclinE proteins on the genesis and progression of human pancreatic cancer
Objective To investigate effect of p27^kipl and cyclinE proteins on the genesis and progression ofhuman pancreatic cancer. Methods The expression of p27^kipl and cyclinE in tumor tissue and adjacent tissue of 32 patients with pancreatic cancer were detected by SP immunohistochemical technique. Results p27^kipl protein postitive-expression rate in tumor tissue of pancreatic cancer was 56%,which was lower than that in adjacent pancreatic tissue(P<0.05),p27^kipl protein positive-expression correlated significantly with tumor cell differentiation and lymphy node metastasis (P<0.05);cyclinE positive-expression rate was 69%, which was higher than that in adjacent pancreatic tissue(P<0.05),cyclinE positive-expression also correlated significantly with tumor cell differentiation and lymphy node metastasis (P<0.05).Conclusions p27^kipl and cyclinE proteins may play an important role in genesis and progression of pancreatic cancer.
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机译：molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines
