Coronavirus disease-2019(COVID-19),a respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a global health emergency and a threat the entire world.The COVID-19 shows a wide spectrum of clinical presentations,severity,and fatality rates.Although the fatal outcomes of the COVID-19 pandemic are evident in all age groups,the most devastating impact on the health consequences and death from COVID-19 are associated with older adults,especially older men.COVID-19 pandemic is affecting different countries in the world especially in the 65+years age male group.In fact,several genes involved into the regulation of the immune system are strategically placed on the X-chromosome and trigger a gendered mediated antiviral fight.The aim of this study is to explore and exploit whether a relationship exists between male sex and COVID-19 mortality and the relationship is age dependent.Herein we discuss the possible role of physiological and immunological sex differences into the higher morbidity and mortality of SARSCoV-2 between females and males.Deciphering gender differences in COVID-19 offers a window into the principles of immunity against SARS-CoV-2 infection and this information on ageing dependent gender disparity might contribute to our current understanding of COVID-19 infection and disease treatment.
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