Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan iMurraya koenigii/i(L.) Spreng

Kartini Ahmad; Siow-Ping Tan; Mohd Aspollah Sukari; Abdul Manaf Ali; Mohd Azlan Nafiah

首页> 中文期刊> 《美国植物学期刊（英文）》 >Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan iMurraya koenigii/i(L.) Spreng

Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan iMurraya koenigii/i(L.) Spreng

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Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.

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《美国植物学期刊（英文）》 |2014年第19期|2869-2877|共9页
作者
Kartini Ahmad; Siow-Ping Tan; Mohd Aspollah Sukari; Abdul Manaf Ali; Mohd Azlan Nafiah;
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作者单位

Department of Chemistry;

Faculty Science and Mathematics;

University Sultan Idris;

Tanjong Malim;

Malaysia;

Department of Chemistry;

Faculty Science;

University Putra Malaysia;

Serdang;

Malaysia;

School of Biotechnology;

Faculty of Agriculture;

Biotechnology & Food Science;

University Sultan Zainal Abidin;

Kuala Terengganu;

Malaysia;

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原文格式 PDF
正文语种 chi
中图分类中药学;
关键词
Carbazole; Rutaceae; Murraya; koenigii; NMR; Cytotoxic;

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Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan iMurraya koenigii/i(L.) Spreng

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