Predicting residue contacts for protein-protein interactions by integration of multiple information

Tu Kien T. Le; Osamu Hirose; Vu Anh Tran; Thammakorn Saethang; Lan Anh T. Nguyen; Xuan Tho Dang; Duc Luu Ngo; Mamoru Kubo; Yoichi Yamada; Kenji Satou

首页> 中文期刊> 《生物医学工程（英文）》 >Predicting residue contacts for protein-protein interactions by integration of multiple information

Predicting residue contacts for protein-protein interactions by integration of multiple information

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Detailed knowledge of interfacial region between interacting proteins is not only helpful in annotating function for proteins, but also very important for structure-based drug design and disease treatment. However, this is one of the most difficult tasks and current methods are constrained by some factors. In this study, we developed a new method to predict residue-residue contacts of two interacting protein domains by integrating information about evolutionary couplings andamino acid pairwise contact potentials, as well as domain-domain interaction interfaces. The experimental results showed that our proposed method outperformed the previous method with the same datasets. Moreover, the method promises an improvement in the source of template-based protein docking.

著录项

来源
《生物医学工程（英文）》 |2014年第1期|28-37|共10页
作者
Tu Kien T. Le; Osamu Hirose; Vu Anh Tran; Thammakorn Saethang; Lan Anh T. Nguyen; Xuan Tho Dang; Duc Luu Ngo; Mamoru Kubo; Yoichi Yamada; Kenji Satou;
展开▼
作者单位

Graduate School of Natural Science and Technology;

Kanazawa University;

Kanazawa;

Japan;

Institute of Science and Engineering;

Kanazawa University;

Kanazawa;

Japan;

展开▼
原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Residue-Residue; Contacts; Domain-Domain; Interactions; Protein-Protein; Interactions; Domain; Interfaces; Residue; Co-Evolution; Contact; Potentials;

相似文献

中文文献
外文文献

Predicting residue contacts for protein-protein interactions by integration of multiple information

摘要

著录项

相似文献

相关主题

期刊订阅