Forskolin Modulates the Inhibitory Effect of C-Type Natriuretic Peptide on Hypoxia-Induced Atrial Dynamics and Hypoxia Inducible Factor 1 Alpha Activity

Chengming Guan; Yanan Jia; Chaochao Bian; Bo Zhang; Dazhi Ding; Xun Cui

首页> 中文期刊> 《生物科学与医学（英文）》 >Forskolin Modulates the Inhibitory Effect of C-Type Natriuretic Peptide on Hypoxia-Induced Atrial Dynamics and Hypoxia Inducible Factor 1 Alpha Activity

Forskolin Modulates the Inhibitory Effect of C-Type Natriuretic Peptide on Hypoxia-Induced Atrial Dynamics and Hypoxia Inducible Factor 1 Alpha Activity

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Our study investigated effects of C-type natriuretic peptide (CNP) on atrial dynamics and hypoxia inducible factor 1 alpha (HIF-1α) activity in perfused beating rat atria, under hypoxic conditions. Hypoxia significantly increased the levels of HIF-1α, concomitant with decreased trial dynamics. CNP (0.1 μmol/L) further decreased atrial dynamics under hypoxia and suppressed hypoxia-induced stimulation of HIF-1α expression. An adenylylcyclase (AC) activator, forskolin (0.1 μmol/L), significantly up-regulated atrial phosphodiesterase subtype 3A (PDE 3A) protein without affecting hypoxia-induced dynamics. In the presence of forskolin, the inhibitory effects of CNP on hypoxia-induced atrial dynamics and HIF-1α levels were significantly attenuated. Forskolin also prevented hypoxia-induced downregulation of PDE3A protein. These findings suggested that CNP inhibited atrial dynamics and HIF-1α activity in the isolated perfused beating rat atria under hypoxic conditions. Furthermore, both effects were modulated by the AC activator forskolin, through activation of CNP-PDE 3A signaling.

著录项

来源
《生物科学与医学（英文）》 |2017年第1期|1-10|共10页
作者
Chengming Guan; Yanan Jia; Chaochao Bian; Bo Zhang; Dazhi Ding; Xun Cui;
展开▼
作者单位

Institue of Clinical Medicine;

Yanbian University;

Yanji;

China;

Department of Physiology;

School of Medicine;

Yanbian University;

Yanji;

China;

Key Laboratory of Organism Functional Factors of the Changbai Mountain;

Ministry of Education;

Yanbian University;

Yanji;

China;

Cellular Function Research Center;

Yanbian University;

Yanji;

China;

展开▼
原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
C-Type; Natriuretic; Peptide; Hypoxia; Inducible; Factor-1α; Phosphodiesterase; Adenylyl; Cyclase; Forskolin;

相似文献

外文文献

Forskolin Modulates the Inhibitory Effect of C-Type Natriuretic Peptide on Hypoxia-Induced Atrial Dynamics and Hypoxia Inducible Factor 1 Alpha Activity

摘要

著录项

相似文献

相关主题

期刊订阅