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《生命科学与技术进展（英文）》
>Expression of miR-155 and miR-146a in Skin Tissue, Peripheral Blood Mononuclear Cells and Serum of Patients with Psoriasis and Its Clinical Significance
Expression of miR-155 and miR-146a in Skin Tissue, Peripheral Blood Mononuclear Cells and Serum of Patients with Psoriasis and Its Clinical Significance
Objective: To explore the expression and clinical significance of miR-155 and miR-146a in psoriasis patients from different sources. Methods: The expression levels of miR-155 and miR-146a in psoriasis vulgaris tissues, peripheral blood mononuclear cells, and serum were detected by the QRT-PCR method in 30 patients with psoriasis vulgaris and 30 healthy subjects as the normal control group, and the correlation between the expression levels of miR-155 and miR-146a in psoriasis samples from different sources was analyzed. And the expression levels of miR-155 and miR-146a in peripheral blood mononuclear cells, and serum after treatment. Results: The expression of miR-155 and miR-146a in skin tissue, peripheral blood mononuclear cells and serum of patients with psoriasis was significantly higher than that of normal controls (P the psoriasis experimental group (P < 0.01). After treatment, the expression of miR-155 and miR-146a in peripheral blood mononuclear cells and serum decreased (P < 0.05). Conclusions: The significantly increased levels of miR-155 and miR-146a in psoriasis samples from different sources may mediate the immune mechanism involved in the activity process of psoriasis.
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机译：NEW RECOMMENDATIONS FOR THE QUALITY AND SAFETY OF TISSUES AND CELLS FOR CLINICAL APPLICATION AND ITS SIGNIFICANCE FOR THE PRACTICE OF TISSUE ESTABLISHMENTS PERFORMING CRYOPRESERVATION
机译：Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment
