Combined Effects of Cd and Hg on Liver and Kidney Histology and Function in Wistar Rats

Karima Dardouri; Samir Haouem; Ines Gharbi; Badreddine Sriha; Zohra Haouas; Abdelhamid El Hani; Mohamed Hammami

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Combined Effects of Cd and Hg on Liver and Kidney Histology and Function in Wistar Rats

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The present study was performed in order to discern the effects of combined exposure to cadmium and mercury on liver function and histopathological alterations in male adult Wistar rats. In the present investigation, cadmium (100 mg/l) and mercury (25 mg/l) were administered orally for 10 weeks separately or in combination. The rational for studying cadmium and mercury is that both of these metals are encountered frequently in the same contaminated areas. In liver, the activities of serum alanine aminotransferase (ALT) and aspartate amino tranferase (AST) increased significantly in the cadmium (Cd) and mercury (Hg) alone or in combination (Cd + Hg) compared to the control suggesting that both cadmium and mercury cause hepatotoxicity spatially when co-administrated. We noted an increase in serum lactate dehydrogenase (LDH) activity in Cd and combined Cd + Hg treated groups while it decreased in Hg treated group. There was no statistically significant change in the level of total bilirubilin. Serum urea concentration showed a significant increase in the Cd and Hg groups compared to the control group. However an increase in serum creatinine concentration was noted only in the combined treated rats showing that renal insufficiency is more serious in the co-exposed group. Light microscopic examination indicated severe histological changes in the two organs under Cd and mercury influence. Results of the present investigation clearly showed that mercury has profound effects of hepatic handling of cadmium (synergistic effect) as shown by histological and biochemical results. Moreover, we observed a antagonist effect between these two toxic metals on kidney markers such as urea.

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来源
《农业化学和环境（英文）》 |2016年第4期|159-169|共11页
作者
Karima Dardouri; Samir Haouem; Ines Gharbi; Badreddine Sriha; Zohra Haouas; Abdelhamid El Hani; Mohamed Hammami;
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作者单位

Department of Physiology;

Faculty of Medicines of Monastir;

University of Monastir;

Monastir;

Tunisia;

Laboratory of Biochemistry;

Research Laboratory LR12 ES 05 Lab-NAFS “Nutrition-Functional Food & Vascular Health”;

Faculty of Medicines;

University of Monastir;

Monastir;

Tunisia;

Laboratory of Biochemistry;

Research Laboratory LR12 ES 05 Lab-NAFS “Nutrition-Functional Food & Vascular Health”Faculty of Medicines;

University of Monastir;

Monastir;

Tunisia;

Laboratory of Pathology;

University Hospital Farhat Hached;

Sousse;

Tunisia;

Laboratory of Histology;

Cytology and Genetics;

Faculty of Medicines of Monastir;

University of Monastir;

Monastir;

Tunisia;

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原文格式 PDF
正文语种 chi
中图分类消化系及腹部疾病;
关键词
Cadmium Chloride; Mercuric Chloride; Hepatotoxicity; Kidney Damage; Rat;

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Combined Effects of Cd and Hg on Liver and Kidney Histology and Function in Wistar Rats

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