Investigation on possible induction of adaptive response(AR)by high-liner energy transfer(LET)particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in utero.This study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal mice.Total body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray radiation.The monoenergetic beams of carbon,silicon and iron with the LET values of about 15,55,and 200 KeV/μm,respectively,were examined.Significant suppression by the priming radiation of the detrimental effects(fetal death,malformation,or low body weight)was used as the endpoints for judgment of a successful AR induction on gestation day 18.Existence of AR was not observed.On the other hand,the priming dose of high-LET particle radiation,in some cases,even increased the detrimental effects induced by the challenge dose from low-LET X-ray radiation.Although existence of AR induced by high-LET radiation in cultured mammalian cells in vitro and in certain tissues of laboratory mice in vivo was demonstrated,the present study did not suggest that low dose of high-LET particle radiation could induce an AR in fetal mice in utero under the setup of our experimental system.
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机译：Radiação, fotossíntese, rendimento e qualidade de frutos em macieiras 'Royal Gala' cobertas com telas antigranizo Radiation, photosynthesis, yield, and fruit quality of 'Royal Gala' apples under hail protection nets
