Implication of gut microbiome in immunotherapy for colorectal cancer

Evangelos Koustas; Eleni-Myrto Trifylli; Panagiotis Sarantis; Nikolaos Papadopoulos; Georgios Aloizos; Ariadne Tsagarakis; Christos Damaskos; Nikolaos Garmpis; Anna Garmpi; Athanasios G Papavassiliou; Michalis V Karamouzis

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Implication of gut microbiome in immunotherapy for colorectal cancer

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Colorectal cancer(CRC) constitutes the third most frequently reported malignancy in the male population and the second most common in women in the last two decades. Colon carcinogenesis is a complex, multifactorial event, resulting from genetic and epigenetic aberrations, the impact of environmental factors, as well as the disturbance of the gut microbial ecosystem. The relationship between the intestinal microbiome and carcinogenesis was relatively undervalued in the last decade. However, its remarkable effect on metabolic and immune functions on the host has been in the spotlight as of recent years. There is a strong relationship between gut microbiome dysbiosis, bowel pathogenicity and responsiveness to anti-cancer treatment;including immunotherapy. Modifications of bacteriome consistency are closely associated with the immunologic response to immunotherapeutic agents. This condition that implies the necessity of gut microbiome manipulation. Thus, creatingan optimal response for CRC patients to immunotherapeutic agents. In this paper, we will review the current literature observing how gut microbiota influence the response of immunotherapy on CRC patients.

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《世界胃肠肿瘤学杂志：英文版（电子版）》 |2022年第9期|1665-1674|共10页
作者
Evangelos Koustas; Eleni-Myrto Trifylli; Panagiotis Sarantis; Nikolaos Papadopoulos; Georgios Aloizos; Ariadne Tsagarakis; Christos Damaskos; Nikolaos Garmpis; Anna Garmpi; Athanasios G Papavassiliou; Michalis V Karamouzis;
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作者单位

Department of Biological Chemistry School and Kapodistrian University of Athens 11527;

1st Department of Internal Medicine Army Share Fund Hospital of Athens 11521;

Beth Israel Deaconess Medical Center 02215 States;

N.S.Christeas Laboratory of Experimental Surgery and Surgical Research School and Kapodistrian University of Athens 11527;

Second Department of Propedeutic Surgery General Hospital School and Kapodistrian University of Athens 11527;

First Department of Pathology School and Kapodistrian University of Athens 11527;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Colorectal cancer; Gut microbiome; IMMUNOTHERAPY; Checkpoint inhibitors; Tumor micro-environment;

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Implication of gut microbiome in immunotherapy for colorectal cancer

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