Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols

Rubina Bibi; Amina Sadiq; Ehsan Ullah Mughal

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Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols

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A series of 4-thioflavonols compounds were synthesized by treating flavonols with lawsons reagent with variable substituent groups at A, B, and AB rings. All the synthesized compounds were checked for antibacterial and antifungal activity. We report that many compounds were found active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, bacterial strains and, C. albicans, C. parapsilosisstrains and C. krusei fungal strains. Most of the synthesized 4-thioflavonols compounds were found to show enhanced antimicrobial activity than respective flavonol compounds.

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《药物化学期刊（英文）》 |2022年第2期|15-25|共11页
作者
Rubina Bibi; Amina Sadiq; Ehsan Ullah Mughal;
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作者单位

Department of Chemistry;

Government College Women University;

Sialkot;

Pakistan;

Department of Chemistry;

University of Gujrat;

Gujrat;

Pakistan;

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原文格式 PDF
正文语种 chi
中图分类有机化学;
关键词
FLAVONOLS; 4-Thioflavonols; FLAVONOIDS; Lawsons Reagent; Antibacterial Activity; Antifungal Activity; One Pot Synthesis; Sulfur Compounds; SAR Studies;

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Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols

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