• 主题
高级搜索  >
历史搜索 清空历史
首页> 中文期刊> 《工程（英文）》 >Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient Survival:A Retrospective Cohort Study Based on an Intelligent Big-Data Platform

Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient Survival:A Retrospective Cohort Study Based on an Intelligent Big-Data Platform

         
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

There is a lack of high-quality,large-scale,real-world evidence from patients with metastatic colorectal cancer(mCRC),especially in China.It remains unclear whether efforts to improve the quality of care for mCRC would improve patient survival outcomes in real-world practice.On the basis of an intelligent bigdata platform,we established a large-scale retrospective cohort of mCRC patients.We investigated the temporal changes in the systemic and local treatment(resection,ablation,or radiation to liver,lung,or extrahepatic and/or extrapulmonary metastases)patterns of mCRC,and whether these changes were associated with improved overall survival(OS)over time.Between July 2012 and December 2018,3403 eligible patients were included in this research.The median OS was 42.8 months(95%confidence interval(CI),40.7–46.6)for the entire cohort,25.6 months(95%CI,24.7–26.9)for those treated with systemic therapy only,and not reached(95%CI,78.6 months–not reached)for those receiving local therapy.The utility rate of local therapy increased continuously from 37.9%in 2012–2014 to 46.9%in 2017–2018.A dramatic increase in the utility rate of either cetuximab or bevacizumab was observed since 2017(39.9%,43.2%,and 60.3%in 2012–2014,2015–2016,and 2017–2018,respectively).Compared with 2012–2014,the OS of the entire population significantly improved in 2015–2016(hazard ratio(HR)=0.87(95%CI,0.78–0.99);P=0.034),but not for patients receiving systemic therapy only(HR=0.99(95%CI,0.86–1.14);P=0.889),whereas an improved OS was found in 2015–2018 for both the entire population(HR=0.75(95%CI,0.70–0.81);P<0.001)and for patients receiving systemic therapy only(HR=0.83(95%CI,0.77–0.91);P<0.001).In summary,the quality of care for mCRC,as indicated by the utility rate of targeted and local therapies,has been continuously improving over time in this study cohort,which is associated with continuously improving survival outcomes for these patients.

著录项

  • 来源
    《工程（英文）》 |2021年第4期|P.526-533|共8页
  • 作者

    Zi-Xian Wang; Yi-Chen Yao; Zong-Jiong Mai; Wu-Hao Lin; You-Sheng Huang; Ying Jin; Hui-Yan Luo; Dong-Sheng Zhang; Feng-Hua Wang; Feng Wang; Gong Chen; Pei-Rong Ding; Yun-Fei Yuan; Yu-Hong Li; Jin-Hua Huang; Zhi-Zhong Pan; Rui-Hua Xu;

  • 作者单位

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaArtificial Intelligence Laboratory Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaArtificial Intelligence Laboratory Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaArtificial Intelligence Laboratory Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 ChinaDepartment of Colorectal Surgery Sun Yat-sen University Cancer Center Guangzhou 510060 China;

    Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 ChinaDepartment of Colorectal Surgery Sun Yat-sen University Cancer Center Guangzhou 510060 China;

    Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 ChinaDepartment of Hepatobiliary Surgery Sun Yat-sen University Cancer Center Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

    Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 ChinaDepartment of Minimally Invasive Therapy Sun Yat-sen University Cancer Center Guangzhou 510060 China;

    Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 ChinaDepartment of Colorectal Surgery Sun Yat-sen University Cancer Center Guangzhou 510060 China;

    Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaArtificial Intelligence Laboratory Sun Yat-sen University Cancer Center Guangzhou 510060 ChinaResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences Guangzhou 510060 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    Metastatic colorectal cancer; Real-world evidence; Treatment pattern; Survival; Big-data platform;

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号