目的:探讨上海市松江区妇幼保健院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)发生的特点和规律,为临床合理用药提供参考.方法:收集我院2016年1月—2017年6月成功上报至国家ADR监测系统的ADR报告90例,采用Excel软件对引发ADR的给药途径、引发ADR的药物种类及具体药品、累及器官和(或)系统及临床表现等进行回顾性统计分析.结果:90例ADR报告中,静脉滴注致ADR病例数最多(49例,占54.44％);ADR涉及9类药物32个品种,以妇产科用药最为多见,例次数排序居前3位的药品分别为硫酸镁注射液、注射用头孢呋辛钠和左炔诺孕酮宫内节育系统;ADR主要累及消化系统,其次为皮肤及其附件.结论:ADR的发生与多种因素有关,临床应加强ADR的监测,增强上报意识,促进合理用药.%OBJECTIVE:To probe into the characteristics and regularities of adverse drug reaction ( ADR) in the Maternal and Child Health Hospital of Songjiang ( hereinafter referred to as"our hospital") , so as to provide reference for clinical rational drug application .METHODS:90 cases of ADR reported to national ADR monitoring system from Jan.2016 to Jun.2017 were collected, Excel was adopted to conduct retrospective analysis on ADR reports in terms of ADR-inducing administration routes , categories of ADR-inducing drugs and specific medicine , ADR involved organs and (or) systems, clinical manifestations, etc.RESULTS: Of the 90 cases of ADR reports, intravenous drip had induced the most ADR; 32 kinds of 9 categories of drugs were involved , mostly was medication in department of gynaecology and obstetrics , the top 3 drugs ranked in the number of ADR cases were respectively magnesium sulfate injection cefuroxime sodium for injection and mirena; ADR mainly involved digestive system , the secondly was skin and its accessories .CONCLUSIONS: The occurrence of ADR was related to various factors , ADR monitoring and reporting should be reinforced to promote rational medication .
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