OBJECTIVE:To investigate the rationality of application of PPI among inpatients in General Hospital of Nanyang Oilfield ( hereinafter referred to as "our hospital") before and after the intervention of clinical pharmacists , and probe into the intervention effects .METHODS:Complete medical records with application of PPI during Jan .-Sep.2016 in our hospital were randomly extracted , of 301 records were during Jan.-Mar.(before intervention), 339 records were during Apr.-Jun.(after the first stage of intervention ) and 306 records were during Jul .-Sep.(after the second stage of intervention ) , the medical records were evaluated and analyzed on the rationality in terms of indications , dosages , solvent selections , administration routes , courses of treatment and drug combinations of PPI .RESULTS:The irrational application rate of PPI among inpatients in our hospital had been decreased from 33.22％ ( 100/301 ) of before intervention to 17.11％(58/339) of the first stage of intervention , and further decreased to 9.48％(29/306) of the second stage of intervention; after intervention , the incidences of unclear indications , overlong courses of treatment , repetitive medications , irrational usages and dosages , inappropriate drug combinations of PPI had been significantly improved than those of before intervention .CONCLUSIONS:After the effective intervention of clinical pharmacists , the application of PPI among inpatients in our hospital is tending to be more rational and standard , which has reflect the positive effects of clinical pharmacists participate in the management of rational application of PPI .%目的:了解临床药师干预前后南阳油田总医院(以下简称"我院")住院患者质子泵抑制剂(proton pump inhibitor,PPI)应用的合理性,探讨干预效果.方法:随机抽取2016年1—9月我院使用过PPI的完整出院病历,其中1—3月(干预前)301份、4—6月(第一阶段干预后)339份和7—9月(第二阶段干预后)306份,对PPI的适应证、用药剂量、溶剂选择、给药途径、疗程及联合用药等方面的合理性进行评价与分析.结果:我院住院患者PPI不合理使用率由干预前的33.22％(100/301)降至第一阶段干预后的17.11％(58/339),并进一步降至第二阶段干预后的9.48(29/306);干预后,PPI使用指征不明确、疗程偏长、重复用药、用法与用量不合理及联合用药不当等情况均较干预前明显改善.结论:经过临床药师的有效干预,我院住院患者PPI的使用趋于合理、规范,体现了临床药师参与PPI合理应用管理的积极作用.
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