OBJECTIVE:To systematically evaluate the efficacy and safety of compound sophora injection in adjuvant treatment of lung cancer .METHODS: PubMed, Embbase, Cochrane library, CNKI, CBM, WanFang database, VIP database, Clinical Trials were retrieved through the keywords "compound sophora injection" till Jun. 2016 , totally 3600 literatures were collected , and RCTs of lung cancer were screened and related information were extracted .Analysis was conducted through Rev Man 5.1 .RESULTS: 1912 cases of patients from 21 literatures relevant with lung cancer were involved .According to Meta-analysis , after treatment , the total effective rate , clinical benefit response rate , Kamofsky score of observation group were significantly higher than those of control group , with extremely significant difference(P<0.01).The incidence of impairment of liver and kidney , constipation, leukocyte decrement and gastrointestinal tract reaction in observation group were significantly lower than those of control group , with statistically significant difference ( P <0.05 ) .CONCLUSIONS: Compound sophora injections on lung cancer adjuvant treatment has certain attenuated synergies , which can improve the patients ' quality of life and reduce the incidence of adverse drug reactions , yet it still needs to be confirmed by clinical experiment research .%目的:系统评价复方苦参注射液治疗肺癌的疗效及安全性.方法:计算机检索PubMed、Embase、Cochrane图书馆、中国期刊全文数据库、中国生物医学文献数据库、万方数字化期刊全文库、维普数据库、Clinical Trials数据库等,通过主题词"复方苦参注射液"检索从建库至2016年6月共3600篇文献,筛选出与肺癌有关的随机对照研究,提取相关资料,采用Rev Man 5.1软件进行文献荟萃(Meta)分析.结果:纳入21篇随机对照研究共1912例肺癌患者.Meta分析结果显示,治疗后,观察组患者总有效率、临床受益率、Kamofsky评分均显著高于对照组,差异有极显著统计学意义(P<0.01);观察组患者肝、肾损害及便秘、白细胞减少症、胃肠道反应发生率均显著低于对照组,差异有统计学意义(P<0.05).结论:复方苦参注射液在肺癌的辅助治疗方面有一定的增效减毒作用,可提高患者患者生活质量,减少部分不良反应的发生,但还需临床进一步研究加以证实.
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