目的:探讨阿托伐他汀联合阿仑膦酸钠治疗骨质疏松症的临床疗效.方法:选择2015年1月-2016年1月深圳市南山区人民医院收治的骨质疏松症患者84例,按随机数字表法分为对照1组、对照2组和观察组,每组28例.对照1组患者给予阿托伐他汀钙片,对照2组患者给予阿仑膦酸钠片,观察组患者给予阿托伐他汀钙片联合阿仑膦酸钠片,比较三组患者的治疗效果.结果:治疗后,三组患者的腰椎、股骨颈及Wards三角区的骨密度均较治疗前上升,且观察组患者上升幅度更为明显,差异均有统计学意义(P<0.05);观察组患者的总有效率为92.86％(26/28),明显高于对照1组的75.00％(21/28)和对照2组的71.43％(20/28),差异均有统计学意义(P<0.05);三组患者均未见明显不良反应.结论:阿托伐他汀联合阿仑膦酸钠治疗骨质疏松症,可明显改善患者骨密度,效果较好,安全性较高.%Objective:To probe into the clinical efficacy of atorvastatin combined with alendronate sodium in treatment of osteoporosis.METHODS: 84 patients with osteoporosis admitted Shenzhen Nanshan District People's Hospital from Jan.2015 to Jan.2016 were selected and divided into control group 1,control group 2 and observation group via the random number table,with 28 cases in each group.The control group 1 was treated with atorvastatin calcium tablets,control group 2 was treated with alendronate sodium tablets,while the observation group was given atorvastatin calcium tablets combined with alendronate sodium.The clinical efficacy of three groups were observed and compared.RESULTS: After treatment,the BMD of lumbar vertebra,neck of femur and Wards trigonum of three groups had been improved compared with before treatment,especially in the observation group,with statistically significant difference(P<0.05);The total effective rate of the observation group(92.86％,26/28)was significantly higher than that of the control group 1(75.00％,21/28)and the control group 2(71.43％,20/28),with statistically significant difference(P<0.05);And there were no serious adverse reactions in any group.CONCLUSIONS: The BMD can be significantly improved by atorvastatin combined with alendronate sodium with better efficacy and safety.
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