OBJECTIVE:To probe into the efficacy of ceftizoxime sodium for injection combined with fusidic acid cream in treatment of sequela ulcer of leprosy .METHODS: 64 patients with sequela ulcer of leprosy admitted into Leprosy Control and Prevention Center of Xiaogan from Nov .2015 to Jun.2017 were selected and divided into observation group and control group via random number table , with 32 cases in each .The control group was treated with ceftizoxime sodium for injection , while the observation group was given fusidic acid cream for external use based on the control group .Differences in clinical efficacy , quality of life ( QOL) scores and incidences of relapse between two groups were compared . RESULTS: The total effective rate of observation group ( 93.75％, 30/32 ) was significantly higher than that of the control group ( 75.00％, 24/32 ) , with statistically significant difference ( P<0.05);at the 8th week after treatment , the QOL score of observation group was significantly higher than that of the control group, with statistically significant differences ( P<0.05); at the 8th week after treatment, the incidence of relapse of observation group (0, 0/32) was significantly lower than that of the control group (21.88％, 7/32), with statistically significant difference ( P <0.05 ).CONCLUSIONS: The efficacy of ceftizoxime sodium for injection combined with fusidic acid cream in treatment of sequela ulcer of leprosy is remarkable , which can improve patients ' ulcer, promote quality of life and reduce the incidence of relapse .%目的:探讨注射用头孢唑肟钠联合夫西地酸乳膏治疗麻风病后遗溃疡的疗效.方法:选取2015年11月—2017年6月湖北省孝感麻风防治中心收治的麻风病后遗溃疡患者64例,根据随机数字表法分为观察组和对照组,每组32例.对照组患者采用注射用头孢唑肟钠治疗,观察组患者在对照组基础上加用夫西地酸乳膏外涂.比较两组患者的临床疗效、生活质量评分及复发情况.结果:观察组患者的总有效率为93.75％(30/32),明显高于对照组的75.00％(24/32),差异有统计学意义(P<0.05);治疗结束第8周,观察组患者的生活质量评分明显高于对照组,差异有统计学意义(P<0.05);治疗结束第8周,观察组患者的复发率为0(0/32),明显低于对照组的21.88％(7/32),差异有统计学意义(P<0.05).结论:注射用头孢唑肟钠联合夫西地酸乳膏治疗麻风病后遗溃疡的疗效显著,可改善患者溃疡情况,提高生活质量,减少复发率.
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