目的:探讨喹硫平与氨磺必利分别治疗老年脑血管病致精神障碍的疗效及安全性.方法:回顾性选取2015年2月—2016年9月锦州市康宁医院收治的老年脑血管病致精神障碍患者82例作为研究对象,根据治疗方式的不同分为观察组和对照组,每组41例.对照组患者给予喹硫平,观察组患者给予氨磺必利,两组患者均治疗2个月.观察两组患者的简明精神病评定量表评分、阴性症状评定量表评分、临床疗效及不良反应发生情况.结果:治疗半个月、1个月和2个月后,两组患者简明精神病评定量表评分和阴性症状评定量表评分较治疗前明显改善,差异均有统计学意义(P0.05);观察组患者的总有效率为95.12％(39/41),明显高于对照组的78.05％(32/41),差异有统计学意义(P0.05);the total effective rate of observation group (95.12％, 39/41) was significantly higher than that of the control group (78.05％, 32/41), with statistically significant difference (P<0.05);the incidence of adverse drug reactions of observation group (14.64％, 6/41) was significantly lower than that of the control group (70.73％, 29/41), with statistically significant difference (P<0.05).CONCLUSIONS:The efficacy of quetiapine and amisulpride in treatment of mental disorder induced by elderly cerebrovascular diseases are both remarkable , yet the amisulpride performed better in efficacy and safety .
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