OBJECTIVE:To probe into the clinical efficacy of extract of Horse chestnut seeds tablets combined with compound lithospermum liquid in treatment of stasis dermatitis .METHODS:120 patients with stasis dermatitis admitted from Mar.2013 to Mar.2015 were selected to be divided into observation group and control group via the random number table , with 60 cases in each.The observation group were given extract of Horse chestnut seeds tablets combined with compound lithospermum liquid in external application , the control group received extract of Horse chestnut seeds tablets combined with dragon ball ointment in external application; the clinical efficacy , symptoms integral , margin of talocrural and stasis dermatitis area in two group of patients were observed .RESULTS: The total effective rate was 95.00%( 57/60 ) in observation group and 78.33%(47/60) in control group, the difference was statistically significant (P <0.05).The symptoms integral was ( 4.20 ±1.20 ) in observation group and ( 8.40 ±1.50 ) in control group , both of which were significantly higher than that of before treatment ( 18.90 ±2.40 ) and ( 19.10 ±2.60 ) , the difference was statistically significant between two groups (P<0.05).Meanwhile, the margin of talocrural and stasis dermatitis area in observation group were(1.88 ±0.57)cm and (4.96+1.51) cm2 , and in control group were (2.89 ±0.52) cm and (7.92+1.45) cm2 , both of which were significantly decreased compared with before treatment , the difference was statistically significant between two groups ( P <0.05 ).CONCLUSIONS: Extract of Horse chestnut seeds tablets combined with compound lithospermum liquid in treatment of stasis dermatitis is effective , which is worthy of clinical promotion .%目的：探讨马栗种子提取物联合复方紫草液治疗淤积性皮炎的疗效。方法：选择2013年3月—2015年3月收治的120例淤积性皮炎患者作为研究对象，按随机数字表法分为观察组与对照组各60例。观察组患者给予马栗种子提取物联合复方紫草液外敷治疗，对照组患者给予马栗种子提取物加龙珠软膏外敷治疗，观察2组患者的疗效及症状、体征改善情况。结果：观察组患者的总有效率为95.00％（57／60），对照组为78.33％（47／60），2组的差异有统计学差异（P＜0.05）。观察组患者治疗后症状积分为（4.20±1.20）分，对照组为（8.40±1.50）分，均明显优于治疗前的（18.90±2.40）、（19.10±2.60）分，且2组间比较，差异有统计学意义（P＜0.05）。观察组患者的小腿周径差、皮炎面积为（1.88±0.57） cm、（4.96＋1.51） cm2，对照组为（2.89±0.52） cm、（7.92＋1.45） cm2，均较治疗前有明显减小，且2组间比较，差异有统计学意义（P＜0.05）。结论：马栗种子提取物联合复方紫草液治疗淤积性皮炎效果较好，值得临床推广。
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